Residue profiles of organohalogen compounds in human serum from e-waste recycling sites in North Vietnam: Association with thyroid hormone levels

This study demonstrated the contamination levels of polychlorinated biphenyls (PCBs), hydroxylated PCBs (OH-PCBs), polybrominated diphenyl ethers (PBDEs), methoxylated PBDEs (MeO-PBDEs), hydroxylated PBDEs (OH-PBDEs), and bromophenols (BPhs), and their relationships with thyroid hormones (THs), in the serum of human donors from an e-waste recycling site and a rural site in Hung Yen province, Vietnam. Occupationally related exposure was indicated by significantly higher residue levels of PCBs, OH-PCBs, PBDEs, and BPhs in the serum of donors from the e-waste recycling site (median: 420, 160, 290, and 300pgg-1 wet wt, respectively) than those in the serum of donors from the rural site (median: 290, 82, 230, and 200pgg- 1 wet wt, respectively). On the other hand, levels of OH-/MeO-PBDEs were significantly higher in serum of donors from the reference site (median: 160 and 20pgg-1 wet wt, respectively) than in those from the e-waste recycling site (median: 43 and 0.52pgg-1 wet wt, respectively). In addition, we implemented stepwise generalized linear models to assess the association between the levels of TH and PCBs, PBDEs, and their related compounds. In females, we found positive associations of PCBs and OH-PCB concentrations with total thyroxine, free thyroxine, total triiodothyronine, and free triiodothyronine, and a negative association with thyroid-stimulating hormone concentrations.

Title: Residue profiles of organohalogen compounds in human serum from e-waste recycling sites in North Vietnam: Association with thyroid hormone levels
Authors: Eguchi, Akifumi
Nomiyama, Kei
Nguyen, Minh Tue
Pham, Thi Kim Trang
Pham, Hung Viet
Takahash, Shin
Tanabe, Shinsuke
Keywords: Thyroid hormones, Hydroxylated metabolites, PBDEs, PCBs, E-waste, Environmental Monitoring
Issue Date: 2015
Publisher: Academic Press Inc.
Citation: Scopus
Abstract: This study demonstrated the contamination levels of polychlorinated biphenyls (PCBs), hydroxylated PCBs (OH-PCBs), polybrominated diphenyl ethers (PBDEs), methoxylated PBDEs (MeO-PBDEs), hydroxylated PBDEs (OH-PBDEs), and bromophenols (BPhs), and their relationships with thyroid hormones (THs), in the serum of human donors from an e-waste recycling site and a rural site in Hung Yen province, Vietnam. Occupationally related exposure was indicated by significantly higher residue levels of PCBs, OH-PCBs, PBDEs, and BPhs in the serum of donors from the e-waste recycling site (median: 420, 160, 290, and 300pgg-1 wet wt, respectively) than those in the serum of donors from the rural site (median: 290, 82, 230, and 200pgg- 1 wet wt, respectively). On the other hand, levels of OH-/MeO-PBDEs were significantly higher in serum of donors from the reference site (median: 160 and 20pgg-1 wet wt, respectively) than in those from the e-waste recycling site (median: 43 and 0.52pgg-1 wet wt, respectively). In addition, we implemented stepwise generalized linear models to assess the association between the levels of TH and PCBs, PBDEs, and their related compounds. In females, we found positive associations of PCBs and OH-PCB concentrations with total thyroxine, free thyroxine, total triiodothyronine, and free triiodothyronine, and a negative association with thyroid-stimulating hormone concentrations.
Description: Environmental Research, Volume 137, February 01, 2015, Pages 440-449
URI: http://www.sciencedirect.com/science/article/pii/S0013935115000080
http://repository.vnu.edu.vn/handle/VNU_123/32575
ISSN: 00139351
Appears in Collections:Bài báo của ĐHQGHN trong Scopus

Nhận xét

Bài đăng phổ biến từ blog này

Thực hiện pháp luật về dân chủ cơ sở ở phường - Qua thực tiễn phường Văn Quán, quận Hà Đông, thành phố Hà Nội : Luận văn ThS. Luật: 60 38 01

Kết quả phẫu thuật cắt nối đại trực tràng điều trị ung thư trực tràng thấp tại bệnh viện giao thông vận tải trung ương

Quan hệ Australia - Việt nam trong giai đoạn 1973 - 1995 : Luận văn TS. Lịch sử: 5 03 04